Changes of Resurgent Na<sup>+</sup> Currents in the Na<sub>v</sub>1.4 Channel Resulting from an <i>SCN4A</i> Mutation Contributing to Sodium Channel Myotonia

Changes of Resurgent Na<sup>+</sup> Currents in the Na<sub>v</sub>1.4 Channel Resulting from an <i>SCN4A</i> Mutation Contributing to Sodium Channel Myotonia

Myotonia congenita (MC) is a rare disorder characterized by stiffness and weakness of the limb and trunk muscles. Mutations in the <i>SCN4A</i> gene encoding the alpha-subunit of the voltage-gated sodium channel Na<sub>v</sub>1.4 have been reported to be responsible for sodiu...

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Bibliographic Details
Main Authors: Chiung-Wei Huang, Hsing-Jung Lai, Pi-Chen Lin, Ming-Jen Lee
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
myotonia congenita
<i>SCN4A</i> mutation
sodium channel
Nav1.4
resurgent current
Online Access:https://www.mdpi.com/1422-0067/21/7/2593

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https://www.mdpi.com/1422-0067/21/7/2593

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