Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

Lipid A from some bacteria is sensed differently by humans and mice for the activation of the inflammasomes and inflammatory responses, but the mechanisms are not clear. Here, the authors show that murine caspase-11 and human caspase-4/5 contribute to this differential response via their distinct re...

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Main Authors: Brice Lagrange, Sacha Benaoudia, Pierre Wallet, Flora Magnotti, Angelina Provost, Fanny Michal, Amandine Martin, Flaviana Di Lorenzo, Bénédicte F. Py, Antonio Molinaro, Thomas Henry
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02682-y
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spelling doaj-383b81a68c0640c08b987c32fdbd2fe22021-05-11T10:05:36ZengNature Publishing GroupNature Communications2041-17232018-01-019111410.1038/s41467-017-02682-yHuman caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11Brice Lagrange0Sacha Benaoudia1Pierre Wallet2Flora Magnotti3Angelina Provost4Fanny Michal5Amandine Martin6Flaviana Di Lorenzo7Bénédicte F. Py8Antonio Molinaro9Thomas Henry10CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ LyonCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ LyonCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ LyonCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ LyonCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ LyonCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ LyonCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ LyonDepartment of Chemical Sciences, University of Napoli Federico II, Complesso Universitario Monte SantangeloCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ LyonDepartment of Chemical Sciences, University of Napoli Federico II, Complesso Universitario Monte SantangeloCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ LyonLipid A from some bacteria is sensed differently by humans and mice for the activation of the inflammasomes and inflammatory responses, but the mechanisms are not clear. Here, the authors show that murine caspase-11 and human caspase-4/5 contribute to this differential response via their distinct recognition of under-acylated lipid A.https://doi.org/10.1038/s41467-017-02682-y
collection DOAJ
language English
format Article
sources DOAJ
author Brice Lagrange
Sacha Benaoudia
Pierre Wallet
Flora Magnotti
Angelina Provost
Fanny Michal
Amandine Martin
Flaviana Di Lorenzo
Bénédicte F. Py
Antonio Molinaro
Thomas Henry
spellingShingle Brice Lagrange
Sacha Benaoudia
Pierre Wallet
Flora Magnotti
Angelina Provost
Fanny Michal
Amandine Martin
Flaviana Di Lorenzo
Bénédicte F. Py
Antonio Molinaro
Thomas Henry
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
Nature Communications
author_facet Brice Lagrange
Sacha Benaoudia
Pierre Wallet
Flora Magnotti
Angelina Provost
Fanny Michal
Amandine Martin
Flaviana Di Lorenzo
Bénédicte F. Py
Antonio Molinaro
Thomas Henry
author_sort Brice Lagrange
title Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
title_short Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
title_full Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
title_fullStr Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
title_full_unstemmed Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
title_sort human caspase-4 detects tetra-acylated lps and cytosolic francisella and functions differently from murine caspase-11
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description Lipid A from some bacteria is sensed differently by humans and mice for the activation of the inflammasomes and inflammatory responses, but the mechanisms are not clear. Here, the authors show that murine caspase-11 and human caspase-4/5 contribute to this differential response via their distinct recognition of under-acylated lipid A.
url https://doi.org/10.1038/s41467-017-02682-y
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