Oral administration of thiol-reducing agents mitigates gut barrier disintegrity and bacterial lipopolysaccharide translocation in a rat model of biliary obstruction

Oral administration of thiol-reducing agents mitigates gut barrier disintegrity and bacterial lipopolysaccharide translocation in a rat model of biliary obstruction

It has been well documented that cirrhosis is associated with the intestinal injury. Intestinal injury in cirrhosis could lead to bacterial lipopolysaccharide (LPS) translocation to the systemic circulation. It has been found that high plasma LPS is connected with higher morbidity and mortality in c...

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Bibliographic Details
Main Authors: Mohammad Mehdi Ommati, Omid Farshad, Hossein Niknahad, Khadijeh Mousavi, Marjan Moein, Negar Azarpira, Hamidreza Mohammadi, Akram Jamshidzadeh, Reza Heidari
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
Bile acids
Cirrhosis
Endotoxemia
Glutathione
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2590257120300031

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http://www.sciencedirect.com/science/article/pii/S2590257120300031

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