The Utility of Iron Chelators in the Management of Inflammatory Disorders

The Utility of Iron Chelators in the Management of Inflammatory Disorders

Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during infl...

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Main Authors: C. Lehmann, S. Islam, S. Jarosch, J. Zhou, D. Hoskin, A. Greenshields, N. Al-Banna, N. Sharawy, A. Sczcesniak, M. Kelly, K. Wafa, W. Cheliak, B. Holbein
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2015/516740
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spelling doaj-382c4f2002ac444081fdb25edc9273082020-11-25T00:22:40ZengHindawi LimitedMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/516740516740The Utility of Iron Chelators in the Management of Inflammatory DisordersC. Lehmann0S. Islam1S. Jarosch2J. Zhou3D. Hoskin4A. Greenshields5N. Al-Banna6N. Sharawy7A. Sczcesniak8M. Kelly9K. Wafa10W. Cheliak11B. Holbein12Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, CanadaDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, CanadaDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, CanadaDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, CanadaDepartment of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, B3H 1X5, CanadaDepartment of Pathology, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, CanadaDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, CanadaDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, CanadaDepartment of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, CanadaDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, CanadaDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, CanadaChelation Partners Inc., 1411 Oxford St., Halifax, NS, B3H 3Z1, CanadaChelation Partners Inc., 1411 Oxford St., Halifax, NS, B3H 3Z1, CanadaSince iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. Under pathological conditions with reduced or increased baseline iron levels different consequences regarding protection or susceptibility to inflammation have to be considered. Given the role of iron in development of inflammatory diseases, pharmaceutical agents targeting this pathway promise to improve the clinical outcome. The objective of this review is to highlight the mechanisms of iron regulation and iron chelation, and to demonstrate the potential impact of this strategy in the management of several acute and chronic inflammatory diseases, including cancer.http://dx.doi.org/10.1155/2015/516740
collection DOAJ
language English
format Article
sources DOAJ
author C. Lehmann
S. Islam
S. Jarosch
J. Zhou
D. Hoskin
A. Greenshields
N. Al-Banna
N. Sharawy
A. Sczcesniak
M. Kelly
K. Wafa
W. Cheliak
B. Holbein
spellingShingle C. Lehmann
S. Islam
S. Jarosch
J. Zhou
D. Hoskin
A. Greenshields
N. Al-Banna
N. Sharawy
A. Sczcesniak
M. Kelly
K. Wafa
W. Cheliak
B. Holbein
The Utility of Iron Chelators in the Management of Inflammatory Disorders
Mediators of Inflammation
author_facet C. Lehmann
S. Islam
S. Jarosch
J. Zhou
D. Hoskin
A. Greenshields
N. Al-Banna
N. Sharawy
A. Sczcesniak
M. Kelly
K. Wafa
W. Cheliak
B. Holbein
author_sort C. Lehmann
title The Utility of Iron Chelators in the Management of Inflammatory Disorders
title_short The Utility of Iron Chelators in the Management of Inflammatory Disorders
title_full The Utility of Iron Chelators in the Management of Inflammatory Disorders
title_fullStr The Utility of Iron Chelators in the Management of Inflammatory Disorders
title_full_unstemmed The Utility of Iron Chelators in the Management of Inflammatory Disorders
title_sort utility of iron chelators in the management of inflammatory disorders
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 2015-01-01
description Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. Under pathological conditions with reduced or increased baseline iron levels different consequences regarding protection or susceptibility to inflammation have to be considered. Given the role of iron in development of inflammatory diseases, pharmaceutical agents targeting this pathway promise to improve the clinical outcome. The objective of this review is to highlight the mechanisms of iron regulation and iron chelation, and to demonstrate the potential impact of this strategy in the management of several acute and chronic inflammatory diseases, including cancer.
url http://dx.doi.org/10.1155/2015/516740
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