Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment

Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment

The Rab27 family of small GTPases regulates exocytosis of distinct vesicle types including multivesicular endosomes, which results in the release of exosomes. Exosomes are nanometer-sized membrane vesicles that enclose soluble factors such as proteins and nucleic acids within a lipid bilayer and can...

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Bibliographic Details
Main Authors: Olivier De Wever, An Hendrix
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:International Journal of Molecular Sciences
Subjects:
Rab GTPase
exosome
cancer
extracellular vesicle
Online Access:http://www.mdpi.com/1422-0067/14/5/9883
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spelling doaj-381d3532a4b44bef81aaf91e0e8da3f72020-11-24T23:55:18ZengMDPI AGInternational Journal of Molecular Sciences1422-00672013-05-011459883989210.3390/ijms14059883Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and TreatmentOlivier De WeverAn HendrixThe Rab27 family of small GTPases regulates exocytosis of distinct vesicle types including multivesicular endosomes, which results in the release of exosomes. Exosomes are nanometer-sized membrane vesicles that enclose soluble factors such as proteins and nucleic acids within a lipid bilayer and can travel toward distant tissues to influence multiple aspects of cell behavior. In our view that tumors are endocrine organs producing exosomes, Rab27 GTPases and their effector proteins are critical determinants for invasive growth and metastasis. Rab27 proteins and their effectors may serve as prognostic biomarkers or as targets for patient-tailored therapy.http://www.mdpi.com/1422-0067/14/5/9883Rab GTPaseexosomecancerextracellular vesicle
collection DOAJ
language English
format Article
sources DOAJ
author Olivier De Wever
An Hendrix
spellingShingle Olivier De Wever
An Hendrix
Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment
International Journal of Molecular Sciences
Rab GTPase
exosome
cancer
extracellular vesicle
author_facet Olivier De Wever
An Hendrix
author_sort Olivier De Wever
title Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment
title_short Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment
title_full Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment
title_fullStr Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment
title_full_unstemmed Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment
title_sort rab27 gtpases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2013-05-01
description The Rab27 family of small GTPases regulates exocytosis of distinct vesicle types including multivesicular endosomes, which results in the release of exosomes. Exosomes are nanometer-sized membrane vesicles that enclose soluble factors such as proteins and nucleic acids within a lipid bilayer and can travel toward distant tissues to influence multiple aspects of cell behavior. In our view that tumors are endocrine organs producing exosomes, Rab27 GTPases and their effector proteins are critical determinants for invasive growth and metastasis. Rab27 proteins and their effectors may serve as prognostic biomarkers or as targets for patient-tailored therapy.
topic Rab GTPase
exosome
cancer
extracellular vesicle
url http://www.mdpi.com/1422-0067/14/5/9883
work_keys_str_mv AT olivierdewever rab27gtpasesdistributeextracellularnanomapsforinvasivegrowthandmetastasisimplicationsforprognosisandtreatment
AT anhendrix rab27gtpasesdistributeextracellularnanomapsforinvasivegrowthandmetastasisimplicationsforprognosisandtreatment
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