Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia

Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia

Show other versions (1)

A 66-year-old women with no history of renal disease was admitted due to a coma and acute kidney injury with a serum creatinine level of 7.44 mg/dL which were ascribed to valacyclovir neurotoxicity and nephrotoxicity, respectively. She had received valacyclovir at a standard dosage for the treatmen...

Full description

Bibliographic Details
Main Authors: Takuya Murakami, Tetsu Akimoto, Mari Okada, Erika Hishida, Taro Sugase, Atsushi Miki, Marina Kohara, Hiromichi Yoshizawa, Takahiro Masuda, Takahisa Kobayashi, Osamu Saito, Shigeaki Muto, Daisuke Nagata
Format: Article
Language:English
Published: AboutScience Srl 2018-06-01
Series:Drug Target Insights
Subjects:
Valacyclovir neurotoxicity
acute kidney injury
hemodialysis
hyponatremia
osmotic demyelination syndrome
Online Access:https://journals.aboutscience.eu/index.php/dti/article/view/1400
id doaj-381bff6053744bb0b3fc1aba06fa220e
record_format Article
spelling doaj-381bff6053744bb0b3fc1aba06fa220e2020-11-25T03:56:02ZengAboutScience SrlDrug Target Insights1177-39282018-06-0112110.33393/dti.2018.1400Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by HyponatremiaTakuya Murakami0Tetsu Akimoto1Mari Okada2Erika Hishida3Taro Sugase4Atsushi Miki5Marina Kohara6Hiromichi Yoshizawa7Takahiro Masuda8Takahisa Kobayashi9Osamu Saito10Shigeaki Muto11Daisuke Nagata12Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan. A 66-year-old women with no history of renal disease was admitted due to a coma and acute kidney injury with a serum creatinine level of 7.44 mg/dL which were ascribed to valacyclovir neurotoxicity and nephrotoxicity, respectively. She had received valacyclovir at a standard dosage for the treatment of herpes zoster and was finally discharged, having fully returned to her normal baseline mental status with a recovered serum creatinine level of 0.68 mg/dL. We feel that awareness of this pathology remains a challenge for physicians and therefore strongly recommend the further accumulation of experiences similar to our own. Our experience underscores the pitfalls of administering valacyclovir to elderly patients who barely appear to have a favorable renal function. Several concerns regarding the therapeutic management, including blood purification strategies, that emerged in this case are also discussed. https://journals.aboutscience.eu/index.php/dti/article/view/1400Valacyclovir neurotoxicityacute kidney injuryhemodialysishyponatremiaosmotic demyelination syndrome
collection DOAJ
language English
format Article
sources DOAJ
author Takuya Murakami
Tetsu Akimoto
Mari Okada
Erika Hishida
Taro Sugase
Atsushi Miki
Marina Kohara
Hiromichi Yoshizawa
Takahiro Masuda
Takahisa Kobayashi
Osamu Saito
Shigeaki Muto
Daisuke Nagata
spellingShingle Takuya Murakami
Tetsu Akimoto
Mari Okada
Erika Hishida
Taro Sugase
Atsushi Miki
Marina Kohara
Hiromichi Yoshizawa
Takahiro Masuda
Takahisa Kobayashi
Osamu Saito
Shigeaki Muto
Daisuke Nagata
Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia
Drug Target Insights
Valacyclovir neurotoxicity
acute kidney injury
hemodialysis
hyponatremia
osmotic demyelination syndrome
author_facet Takuya Murakami
Tetsu Akimoto
Mari Okada
Erika Hishida
Taro Sugase
Atsushi Miki
Marina Kohara
Hiromichi Yoshizawa
Takahiro Masuda
Takahisa Kobayashi
Osamu Saito
Shigeaki Muto
Daisuke Nagata
author_sort Takuya Murakami
title Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia
title_short Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia
title_full Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia
title_fullStr Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia
title_full_unstemmed Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia
title_sort valacyclovir neurotoxicity and nephrotoxicity in an elderly patient complicated by hyponatremia
publisher AboutScience Srl
series Drug Target Insights
issn 1177-3928
publishDate 2018-06-01
description A 66-year-old women with no history of renal disease was admitted due to a coma and acute kidney injury with a serum creatinine level of 7.44 mg/dL which were ascribed to valacyclovir neurotoxicity and nephrotoxicity, respectively. She had received valacyclovir at a standard dosage for the treatment of herpes zoster and was finally discharged, having fully returned to her normal baseline mental status with a recovered serum creatinine level of 0.68 mg/dL. We feel that awareness of this pathology remains a challenge for physicians and therefore strongly recommend the further accumulation of experiences similar to our own. Our experience underscores the pitfalls of administering valacyclovir to elderly patients who barely appear to have a favorable renal function. Several concerns regarding the therapeutic management, including blood purification strategies, that emerged in this case are also discussed.
topic Valacyclovir neurotoxicity
acute kidney injury
hemodialysis
hyponatremia
osmotic demyelination syndrome
url https://journals.aboutscience.eu/index.php/dti/article/view/1400
work_keys_str_mv AT takuyamurakami valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT tetsuakimoto valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT mariokada valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT erikahishida valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT tarosugase valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT atsushimiki valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT marinakohara valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT hiromichiyoshizawa valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT takahiromasuda valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT takahisakobayashi valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT osamusaito valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT shigeakimuto valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
AT daisukenagata valacyclovirneurotoxicityandnephrotoxicityinanelderlypatientcomplicatedbyhyponatremia
_version_ 1724466597700042752

Similar Items