17β-Estradiol Promotes Proinflammatory and Procoagulatory Phenotype of Innate Immune Cells in the Presence of Antiphospholipid Antibodies

17β-Estradiol Promotes Proinflammatory and Procoagulatory Phenotype of Innate Immune Cells in the Presence of Antiphospholipid Antibodies

Antiphospholipid syndrome (APS) is the most common cause of acquired thrombophilia and recurrent spontaneous miscarriages associated with extended persistence of antiphospholipid antibodies (aPL). How circulating aPL and high-17β-estradiol (E2) environment contribute to the pregnancy complications i...

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Bibliographic Details
Main Authors: Gayane Manukyan, Anush Martirosyan, Ludek Slavik, Jana Ulehlova, Martin Dihel, Tomas Papajik, Eva Kriegova
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomedicines
Subjects:
antiphospholipid syndrome
antiphospholipid antibodies
estradiol
tissue factor
monocytes
in vitro
Online Access:https://www.mdpi.com/2227-9059/8/6/162

Internet

https://www.mdpi.com/2227-9059/8/6/162

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