Engineering production of functional scFv antibody in E. coli by co-expressing the molecule chaperone Skp

Engineering production of functional scFv antibody in E. coli by co-expressing the molecule chaperone Skp

Single-chain variable fragment (scFv) is a class of engineered antibodies generated by the fusion of the heavy (VH) and light chains (VL) of immunoglobulins through a short polypeptide linker. ScFv play a critical role in therapy and diagnosis of human diseases, and may in fact also be developed int...

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Bibliographic Details
Main Authors: Rongzhi eWang, Shuangshuang eXiang, Youjun eFeng, Swaminath eSrinivas, Yonghui eZhang, Mingshen eLin, Shihua eWang
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Solubility
Vibrio parahaemolyticus
co-expression
production
scFv
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00072/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00072/full

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