Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells

Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells

Human amylin is a 37-residue peptide hormone (hA1-37) secreted by β-cells of the pancreas and, along with insulin, is directly associated with type 2 diabetes mellitus (T2DM). Amyloid deposits within the islets of the pancreas represent a hallmark of T2DM. Additionally, amylin aggregates ha...

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Bibliographic Details
Main Authors: Giuseppe Caruso, Claudia G. Fresta, Giacomo Lazzarino, Donatella A. Distefano, Paolo Parlascino, Susan M. Lunte, Giuseppe Lazzarino, Filippo Caraci
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
amylin
β-amyloid
Alzheimer’s disease
vascular endothelial growth factor
HspB5
neuroprotection
Online Access:https://www.mdpi.com/1422-0067/19/11/3659

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