Glutamate Levels and Resting Cerebral Blood Flow in Anterior Cingulate Cortex Are Associated at Rest and Immediately Following Infusion of S-Ketamine in Healthy Volunteers

Glutamate Levels and Resting Cerebral Blood Flow in Anterior Cingulate Cortex Are Associated at Rest and Immediately Following Infusion of S-Ketamine in Healthy Volunteers

Progressive loss of brain tissue is seen in some patients with schizophrenia and might be caused by increased levels of glutamate and resting cerebral blood flow (rCBF) alterations. Animal studies suggest that the normalisation of glutamate levels decreases rCBF and prevents structural changes in hi...

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Bibliographic Details
Main Authors: Kirsten Borup Bojesen, Kasper Aagaard Andersen, Sophie Nordahl Rasmussen, Lone Baandrup, Line Malmer Madsen, Birte Yding Glenthøj, Egill Rostrup, Brian Villumsen Broberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Psychiatry
Subjects:
glutamate
magnetic resonance spectroscopy
cerebral blood flow
pseudo-continuous arterial spin labelling
ketamine
schizophrenia
Online Access:http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00022/full

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