Desenvolvimento e validação de um método analítico simples e rápido por espectroscopia UV para quantificação de aciclovir em matrizes hidrofílicas de liberação prolongada Development and validation of a simple and rapid analytical method by UV spectroscopy for acyclovir quantification in hydrophilic matrices for sustained release

• Main Authors: Fernanda Malaquias Barboza, Débora Dalla Vecchia, Airton Vicente Pereira, Hellen Karine Stulzer, Marcos Antonio Segatto Silva
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2010-01-01
• Series: Química Nova
• Subjects: acyclovir; hydrophilic matrices; UV spectrophotometry
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000300047
• ISSN: 0100-4042; 1678-7064

<abstract language="eng">This work reports the validation of an analytical UV spectrophotometric method to assay acyclovir in hydrophilic matrices (assay and dissolution studies). The method was linear in the range between 2.5-20 µg mL-1, presenting a good correlation coefficient ( r = 0,9999). Precision and accuracy analysis showed low relative standart deviation (< 2.0 %) and a good recoveries percentual (98.9-100 %). The procedure was linear, accurate, and robust. The method is simple and cheap. It does not use polluting reagents and can be applied in dissolution studies, being an adequate alternative to assay acyclovir in hydrophilic matrices tablets.