IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells

XLP-2 syndrome is caused by XIAP mutation. Here the authors show that mouse and human XIAP-deficient regulatory T cells have defective suppressive function as a result of conversion to proinflammatory cytokine producing cells, an effect that can be prevented by blocking the IL-6 receptor.

Bibliographic Details
Main Authors: Wan-Chen Hsieh, Tzu-Sheng Hsu, Ya-Jen Chang, Ming-Zong Lai
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-02862-4
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spelling doaj-37de1a9a384e45eba015976455f5d58b2021-05-11T10:06:58ZengNature Publishing GroupNature Communications2041-17232018-01-019111510.1038/s41467-018-02862-4IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cellsWan-Chen Hsieh0Tzu-Sheng Hsu1Ya-Jen Chang2Ming-Zong Lai3Institute of Molecular Biology, Academia Sinica, Academia SinicaInstitute of Molecular Biology, Academia Sinica, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Molecular Biology, Academia Sinica, Academia SinicaXLP-2 syndrome is caused by XIAP mutation. Here the authors show that mouse and human XIAP-deficient regulatory T cells have defective suppressive function as a result of conversion to proinflammatory cytokine producing cells, an effect that can be prevented by blocking the IL-6 receptor.https://doi.org/10.1038/s41467-018-02862-4
collection DOAJ
language English
format Article
sources DOAJ
author Wan-Chen Hsieh
Tzu-Sheng Hsu
Ya-Jen Chang
Ming-Zong Lai
spellingShingle Wan-Chen Hsieh
Tzu-Sheng Hsu
Ya-Jen Chang
Ming-Zong Lai
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
Nature Communications
author_facet Wan-Chen Hsieh
Tzu-Sheng Hsu
Ya-Jen Chang
Ming-Zong Lai
author_sort Wan-Chen Hsieh
title IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
title_short IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
title_full IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
title_fullStr IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
title_full_unstemmed IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
title_sort il-6 receptor blockade corrects defects of xiap-deficient regulatory t cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description XLP-2 syndrome is caused by XIAP mutation. Here the authors show that mouse and human XIAP-deficient regulatory T cells have defective suppressive function as a result of conversion to proinflammatory cytokine producing cells, an effect that can be prevented by blocking the IL-6 receptor.
url https://doi.org/10.1038/s41467-018-02862-4
work_keys_str_mv AT wanchenhsieh il6receptorblockadecorrectsdefectsofxiapdeficientregulatorytcells
AT tzushenghsu il6receptorblockadecorrectsdefectsofxiapdeficientregulatorytcells
AT yajenchang il6receptorblockadecorrectsdefectsofxiapdeficientregulatorytcells
AT mingzonglai il6receptorblockadecorrectsdefectsofxiapdeficientregulatorytcells
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