Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors

Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors

Summary: We previously reported the generation of integration-free induced pluripotent stem cells from adult peripheral blood (PB) with an improved episomal vector (EV) system, which uses the spleen focus-forming virus U3 promoter and an extra factor BCL-XL (B). Here we show an ∼100-fold increase in...

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Bibliographic Details
Main Authors: Wei Wen, Jian-Ping Zhang, Jing Xu, Ruijun Jeanna Su, Amanda Neises, Guang-Zhen Ji, Weiping Yuan, Tao Cheng, Xiao-Bing Zhang
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116300303

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