Dopamine D<sub>2</sub> Receptor Agonist Binding Kinetics—Role of a Conserved Serine Residue

Dopamine D<sub>2</sub> Receptor Agonist Binding Kinetics—Role of a Conserved Serine Residue

The forward (k<sub>on</sub>) and reverse (k<sub>off</sub>) rate constants of drug–target interactions have important implications for therapeutic efficacy. Hence, time-resolved assays capable of measuring these binding rate constants may be informative to drug discovery effor...

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Bibliographic Details
Main Authors: Richard Ågren, Tomasz Maciej Stepniewski, Hugo Zeberg, Jana Selent, Kristoffer Sahlholm
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Xenopus</i> oocytes
electrophysiology
voltage-clamp
molecular dynamics simulation
G protein-coupled receptor
phenethylamines
Online Access:https://www.mdpi.com/1422-0067/22/8/4078

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