Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology
Sphingolipid metabolism is deeply regulated along the differentiation and development of the central nervous system (CNS), and the expression of a peculiar spatially and temporarily regulated sphingolipid pattern is essential for the maintenance of the functional integrity of the nervous system. Mic...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2013-01-01
|
Series: | Clinical and Developmental Immunology |
Online Access: | http://dx.doi.org/10.1155/2013/309302 |
id |
doaj-37cce1913ab34970bd5a77ce19f1dfb5 |
---|---|
record_format |
Article |
spelling |
doaj-37cce1913ab34970bd5a77ce19f1dfb52020-11-24T23:11:21ZengHindawi LimitedClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/309302309302Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System PathologyEmma Assi0Denise Cazzato1Clara De Palma2Cristiana Perrotta3Emilio Clementi4Davide Cervia5Department of Biomedical and Clinical Sciences, Unit of Clinical Pharmacology, CNR Institute of Neuroscience, “Luigi Sacco” University Hospital, University of Milan, 20157 Milan, ItalyDepartment of Biomedical and Clinical Sciences, Unit of Clinical Pharmacology, CNR Institute of Neuroscience, “Luigi Sacco” University Hospital, University of Milan, 20157 Milan, ItalyDepartment of Biomedical and Clinical Sciences, Unit of Clinical Pharmacology, CNR Institute of Neuroscience, “Luigi Sacco” University Hospital, University of Milan, 20157 Milan, ItalyDepartment of Biomedical and Clinical Sciences, Unit of Clinical Pharmacology, CNR Institute of Neuroscience, “Luigi Sacco” University Hospital, University of Milan, 20157 Milan, ItalyDepartment of Biomedical and Clinical Sciences, Unit of Clinical Pharmacology, CNR Institute of Neuroscience, “Luigi Sacco” University Hospital, University of Milan, 20157 Milan, ItalyDepartment of Biomedical and Clinical Sciences, Unit of Clinical Pharmacology, CNR Institute of Neuroscience, “Luigi Sacco” University Hospital, University of Milan, 20157 Milan, ItalySphingolipid metabolism is deeply regulated along the differentiation and development of the central nervous system (CNS), and the expression of a peculiar spatially and temporarily regulated sphingolipid pattern is essential for the maintenance of the functional integrity of the nervous system. Microglia are resident macrophages of the CNS involved in general maintenance of neural environment. Modulations in microglia phenotypes may contribute to pathogenic forms of inflammation. Since defects in macrophage/microglia activity contribute to neurodegenerative diseases, it will be essential to systematically identify the components of the microglial cell response that contribute to disease progression. In such complex processes, the sphingolipid systems have recently emerged to play important roles, thus appearing as a key new player in CNS disorders. This review provides a rationale for harnessing the sphingolipid metabolic pathway as a potential target against neuroinflammation.http://dx.doi.org/10.1155/2013/309302 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emma Assi Denise Cazzato Clara De Palma Cristiana Perrotta Emilio Clementi Davide Cervia |
spellingShingle |
Emma Assi Denise Cazzato Clara De Palma Cristiana Perrotta Emilio Clementi Davide Cervia Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology Clinical and Developmental Immunology |
author_facet |
Emma Assi Denise Cazzato Clara De Palma Cristiana Perrotta Emilio Clementi Davide Cervia |
author_sort |
Emma Assi |
title |
Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology |
title_short |
Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology |
title_full |
Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology |
title_fullStr |
Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology |
title_full_unstemmed |
Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology |
title_sort |
sphingolipids and brain resident macrophages in neuroinflammation: an emerging aspect of nervous system pathology |
publisher |
Hindawi Limited |
series |
Clinical and Developmental Immunology |
issn |
1740-2522 1740-2530 |
publishDate |
2013-01-01 |
description |
Sphingolipid metabolism is deeply regulated along the differentiation and development of the central nervous system (CNS), and the expression of a peculiar spatially and temporarily regulated sphingolipid pattern is essential for the maintenance of the functional integrity of the nervous system. Microglia are resident macrophages of the CNS involved in general maintenance of neural environment. Modulations in microglia phenotypes may contribute to pathogenic forms of inflammation. Since defects in macrophage/microglia activity contribute to neurodegenerative diseases, it will be essential to systematically identify the components of the microglial cell response that contribute to disease progression. In such complex processes, the sphingolipid systems have recently emerged to play important roles, thus appearing as a key new player in CNS disorders. This review provides a rationale for harnessing the sphingolipid metabolic pathway as a potential target against neuroinflammation. |
url |
http://dx.doi.org/10.1155/2013/309302 |
work_keys_str_mv |
AT emmaassi sphingolipidsandbrainresidentmacrophagesinneuroinflammationanemergingaspectofnervoussystempathology AT denisecazzato sphingolipidsandbrainresidentmacrophagesinneuroinflammationanemergingaspectofnervoussystempathology AT claradepalma sphingolipidsandbrainresidentmacrophagesinneuroinflammationanemergingaspectofnervoussystempathology AT cristianaperrotta sphingolipidsandbrainresidentmacrophagesinneuroinflammationanemergingaspectofnervoussystempathology AT emilioclementi sphingolipidsandbrainresidentmacrophagesinneuroinflammationanemergingaspectofnervoussystempathology AT davidecervia sphingolipidsandbrainresidentmacrophagesinneuroinflammationanemergingaspectofnervoussystempathology |
_version_ |
1725604796489007104 |