Tubule-specific protein nanocages potentiate targeted renal fibrosis therapy

Tubule-specific protein nanocages potentiate targeted renal fibrosis therapy

Abstract Background Despite the dramatic advances in modern medicine, efficient therapeutic measures for renal fibrosis remain limited. Celastrol (CLT) is effective in treating renal fibrosis in rat models, while causing severe systemic toxicity. Thus, we designed a tubule-specific nanocage (K3-HBc...

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Bibliographic Details
Main Authors: Xuan Zhang, Qian Chen, Liyuan Zhang, Haiping Zheng, Chunjie Lin, Qunfang Yang, Tao Liu, Haigang Zhang, Xiaohong Chen, Lei Ren, Wenjun Shan
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Nanobiotechnology
Subjects:
Protein nanocage
Celastrol
Target therapy
Cell senescence
Renal fibrosis
Online Access:https://doi.org/10.1186/s12951-021-00900-w

Internet

https://doi.org/10.1186/s12951-021-00900-w

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