Interleukin-6 and highly sensitive C-reactive protein in obese adolescents
Background Childhood obesity is a major health concern. Obesity is due to an expansion of adipose tissue mass. This tissue produces proinflarmnatory cytokines, such as interleukin6 (IL--6). IL6 is considered to be the chief stimulator of the production of highly sensitive Creactive protein (hsCR...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Indonesian Pediatric Society Publishing House
2012-08-01
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Series: | Paediatrica Indonesiana |
Subjects: | |
Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/400 |
Summary: | Background Childhood obesity is a major health concern.
Obesity is due to an expansion of adipose tissue mass. This tissue
produces proinflarmnatory cytokines, such as interleukin6 (IL--6).
IL6 is considered to be the chief stimulator of the production of
highly sensitive Creactive protein (hsCRP) in the liver. Both
molecules are responsible for the chronic lowgrade inflammatory
state in obese individuals.
Objective To assess a correlation between IL6 and hsCRP in
obese adolescents.
Methods This crosssectional study was conducted from March
to June 2011 in Manado. Subjects were obese and normal body
mass index (BMI) teens aged 1318 years. Serum glutamic
oxaloacetic transaminase (SOOT) and serum glutamic pyruvic
transaminase (SOPT) levels were measured to rule out liver
impairment. IL6 and hsCRP levels were also measured. Data was
analyzed by Pearson's correlation and linear regression to test for
correlation between IL--6 and hsCRP levels.
Results There was a strongly positive correlation between IL6
and hsCRP levels in obese adolescents (r=0.79 with P<O.OOl).
IL--6 and hsCRP levels were not significantly associated in subjects
with normal BMI.
Conclusions There was a strongly positive correlation between
IL--6 and hsCRP levels in obese adolescents, suggestive of an
ongoing, chronic, lowgrade inflammatory state. [Paediatr
Indanes.2012;52:219-22]. |
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ISSN: | 0030-9311 2338-476X |