| Summary: | Acne is an inflammatory skin disorder in puberty with symptoms including papules, folliculitis, and nodules. <i>Propionibacterium acnes</i> (<i>P. acnes</i>) is the main anaerobic bacteria that cause acne. It is known to proliferate within sebum-blocked skin hair follicles. <i>P. acnes</i> activates monocytic cell immune responses to induce the expression of proinflammatory cytokines. Although the anti-inflammatory function of the <i>Laurus nobilis</i> (<i>L. nobilis</i>) extract (LNE) on several immunological disorders have been reported, the effect of LNE in <i>P. acnes</i>-mediated skin inflammation has not yet been explored. In the present study, we examined the ability of the LNE to modulate the <i>P. acnes</i>-induced inflammatory signaling pathway, and evaluated its mechanism. LNE significantly suppressed the expression of <i>P. acnes</i>-mediated proinflammatory cytokines, such as IL-1β, IL-6, and NLRP3. We also found that LNE inhibited the inflammatory transcription factor NF-κB in response to <i>P. acnes</i>. In addition, eucalyptol, which is the main constituent of LNE, consistently inhibited <i>P. acnes</i>-induced inflammatory signaling pathways. Moreover, LNE significantly ameliorated <i>P. acnes</i>-induced inflammation in a mouse model of acne. We suggest for the first time that LNE hold therapeutic value for the improvement of <i>P. acnes</i>-induced skin inflammation.
|
|---|
