HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation

HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation

Abstract Adverse birth outcomes are common in HIV-positive pregnant women receiving combination antiretroviral therapy (cART), especially when cART is initiated in early pregnancy. The mechanisms remain poorly understood. Using a mouse model we demonstrate that protease inhibitor based-cART exposure...

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Bibliographic Details
Main Authors: Hakimeh Mohammadi, Eszter Papp, Lindsay Cahill, Monique Rennie, Nicole Banko, Lakmini Pinnaduwage, Janice Lee, Mark Kibschull, Caroline Dunk, John G. Sled, Lena Serghides
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-24680-w

Internet

https://doi.org/10.1038/s41598-018-24680-w

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