Crystal structure of a human single domain antibody dimer formed through V(H)-V(H) non-covalent interactions.

Crystal structure of a human single domain antibody dimer formed through V(H)-V(H) non-covalent interactions.

Single-domain antibodies (sdAbs) derived from human V(H) are considered to be less soluble and prone to aggregate which makes it difficult to determine the crystal structures. In this study, we isolated and characterized two anti-human epidermal growth factor receptor-2 (HER2) sdAbs, Gr3 and Gr6, fr...

Full description

Bibliographic Details
Main Authors:	Toya Nath Baral, Shi-Yu Chao, Shenghua Li, Jamshid Tanha, Mehdi Arbabi-Ghahroudi, Jianbing Zhang, Shuying Wang
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3257273?pdf=render

Similar Items

Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook
by: Mehdi Arbabi-Ghahroudi, et al.
Published: (2017-11-01)

Tuning the Polymorphism of the Anti-VEGF G-rich V7t1 Aptamer by Covalent Dimeric Constructs
by: Claudia Riccardi, et al.
Published: (2020-03-01)

Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases
by: Dakshinamurthy Sivakumar, et al.
Published: (2021-05-01)

Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization.
by: Tine N Vinther, et al.
Published: (2012-01-01)

Insights into Comparative Modeling of V<sub>H</sub>H Domains
by: Akhila Melarkode Vattekatte, et al.
Published: (2021-09-01)

Dimeric DNA Aptamer Complexes for High-capacity–targeted Drug Delivery Using pH-sensitive Covalent Linkages
by: Olcay Boyacioglu, et al.
Published: (2013-01-01)

Dopant Effect of Covalent Structures on H-bonded Banana-shaped Liquid Crystals
by: 江奕宏
Published: (2008)

In vivo neutralization of α-cobratoxin with high-affinity llama single-domain antibodies (VHHs) and a VHH-Fc antibody.
by: Gabrielle Richard, et al.
Published: (2013-01-01)

H_v-Fields, h/v-Fields
by: Thomas Vougiouklis
Published: (2017-12-01)

Contribution of V(H) replacement products in mouse antibody repertoire.
by: Lin Huang, et al.
Published: (2013-01-01)

A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display
by: Greg Hussack, et al.
Published: (2017-10-01)

Fab Fragment of V<sub>H</sub>H-Based Antibody Netakimab: Crystal Structure and Modeling Interaction with Cytokine IL-17A
by: Olga Kostareva, et al.
Published: (2019-03-01)

Covalent α-synuclein dimers: chemico-physical and aggregation properties.
by: Micaela Pivato, et al.
Published: (2012-01-01)

Essential Role of Covalent Linkage between the Chymotrypsin-Like Domain and the Extra Domain in SARS-CoV Main Protease
by: Meng-Ying Tsai, et al.
Published: (2008)

Engineered single-domain antibodies with high protease resistance and thermal stability.
by: Greg Hussack, et al.
Published: (2011-01-01)

Study of Polymer Dopant Effects on Covalent-Bonded and H-Bonded Bent-Core Liquid Crystals
by: 湯捷茵
Published: (2008)

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability
by: Vinojini B. Nair, et al.
Published: (2015-01-01)

A conserved hydrophobic patch on Vβ domains revealed by TCRβ chain crystal structures: implications for pre-TCR dimerization
by: Bo eZhou, et al.
Published: (2011-03-01)

Self-Assembly of Covalently Linked Porphyrin Dimers at the Solid–Liquid Interface
by: Thomas Habets, et al.
Published: (2019-08-01)

A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies.
by: Kevin A Henry, et al.
Published: (2016-01-01)

Multivalent Anchoring and Oriented Display of Single-Domain Antibodies on Cellulose
by: Roger MacKenzie, et al.
Published: (2009-07-01)

Immunobiology of African Trypanosomes: Need of Alternative Interventions
by: Toya Nath Baral
Published: (2010-01-01)

Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases
by: Kasandra Bélanger, et al.
Published: (2019-04-01)

Production and Characterization of Monoclonal Antibodies Against the Dimerization Domain of Human HER2
by: Nadri, et al.
Published: (2015-07-01)

Beyond phage display: Non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic and bioconjugation scaffold
by: Kevin Alexander Henry, et al.
Published: (2015-08-01)

Dimerization Tendency of 3CLpros of Human Coronaviruses Based on the X-ray Crystal Structure of the Catalytic Domain of SARS-CoV-2 3CLpro
by: Jo, S., et al.
Published: (2022)

Development of a covalent site-specific antibody labeling strategy by the use of photoactivable Z domains
by: Konrad, Anna
Published: (2012)

Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188
by: Gordon J. Lockbaum, et al.
Published: (2021-01-01)

Toxin-Specific Antibodies for the Treatment of Clostridium difficile: Current Status and Future Perspectives
by: Greg Hussack, et al.
Published: (2010-05-01)

Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease
by: Pietro Delre, et al.
Published: (2020-11-01)

The v1 and v3 bands of H2 160 and H2 180 /
by: Fraley, Phillip Edward
Published: (1966)

Mass spectroscopy of 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-7-thioxo-7,8-dihydro-6H-pyrimido[4,5-c]pyridazine-5-ones: Dimers containing water cluster and quasi-covalent hydrogen bond
by: Nader Noroozi Pesyan, et al.
Published: (2013-10-01)

Crystal structure of pentakispiperidyltantal(V), Ta(NC5H10)5
by: Engering J., et al.
Published: (2003-06-01)

Unveiling how intramolecular stacking modes of covalently linked dimers dictate photoswitching properties
by: Ru-Qiang Lu, et al.
Published: (2019-12-01)

Unified model for singlet fission within a non-conjugated covalent pentacene dimer
by: Bettina S. Basel, et al.
Published: (2017-05-01)

A Symmetry Exploration into Covalent Tetracene Dimers with Tunable Electronic Coupling for Singlet Fission
by: Snyder, Jamie Lynn
Published: (2015)

Detectability of H2-Ar and H2-Ne Dimers in Jovian Atmospheres
by: Young-Key Minn, et al.
Published: (1997-12-01)

Pentavalent single-domain antibodies reduce Campylobacter jejuni motility and colonization in chickens.
by: Ali Riazi, et al.
Published: (2013-01-01)

Creation Description of "V.H.S."
by: Chun-Wei Chen, et al.
Published: (2015)

Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries
by: Kevin A. Henry, et al.
Published: (2017-12-01)

Cannot write session to /tmp/vufind_sessions/sess_3dnj8nheigaqrbder4gkpn09vi