A New Pentacyclic Triterpene from Humata tyermanni Moore with the Inhibitory Activities against LPS-Induced NO Production in RAW264.7 Macrophages

A New Pentacyclic Triterpene from Humata tyermanni Moore with the Inhibitory Activities against LPS-Induced NO Production in RAW264.7 Macrophages

One new pentacyclic triterpene, hopane-22 (29)-en-24ol (2), with five known hopane-type pentacyclic triterpene compounds: hop-22(29)-ene (1), adiantone (3), 22-hydroxyhopane (4), 6α, 22-dihydroxyhopane (5), and 17(21)-hopene (6) were isolated from Humata tyermanni Moore. The structure of compound 2...

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Main Authors: Lei Zhang, Feng Wang, Zhen-You Jiang, Yao-Kui Zhu, Ying-Zhou Cen
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2013/727136
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spelling doaj-379a0ac5befc41faa724e20d8c7c894b2020-11-25T00:45:36ZengHindawi LimitedJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/727136727136A New Pentacyclic Triterpene from Humata tyermanni Moore with the Inhibitory Activities against LPS-Induced NO Production in RAW264.7 MacrophagesLei Zhang0Feng Wang1Zhen-You Jiang2Yao-Kui Zhu3Ying-Zhou Cen4Department of Chemistry, Jinan University, Guangzhou 510632, ChinaShenzhen Guangming New District Environmental Monitoring Station, Shenzhen Guangming City Construction Bureau, Shenzhen 518107, ChinaDepartment of Microbiology and Immunology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Chemistry, Jinan University, Guangzhou 510632, ChinaDepartment of Chemistry, Jinan University, Guangzhou 510632, ChinaOne new pentacyclic triterpene, hopane-22 (29)-en-24ol (2), with five known hopane-type pentacyclic triterpene compounds: hop-22(29)-ene (1), adiantone (3), 22-hydroxyhopane (4), 6α, 22-dihydroxyhopane (5), and 17(21)-hopene (6) were isolated from Humata tyermanni Moore. The structure of compound 2 was elucidated on the basis of its 1D and 2D NMR spectral analysis. All these compounds were evaluated for their inhibitory activities of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages.http://dx.doi.org/10.1155/2013/727136
collection DOAJ
language English
format Article
sources DOAJ
author Lei Zhang
Feng Wang
Zhen-You Jiang
Yao-Kui Zhu
Ying-Zhou Cen
spellingShingle Lei Zhang
Feng Wang
Zhen-You Jiang
Yao-Kui Zhu
Ying-Zhou Cen
A New Pentacyclic Triterpene from Humata tyermanni Moore with the Inhibitory Activities against LPS-Induced NO Production in RAW264.7 Macrophages
Journal of Chemistry
author_facet Lei Zhang
Feng Wang
Zhen-You Jiang
Yao-Kui Zhu
Ying-Zhou Cen
author_sort Lei Zhang
title A New Pentacyclic Triterpene from Humata tyermanni Moore with the Inhibitory Activities against LPS-Induced NO Production in RAW264.7 Macrophages
title_short A New Pentacyclic Triterpene from Humata tyermanni Moore with the Inhibitory Activities against LPS-Induced NO Production in RAW264.7 Macrophages
title_full A New Pentacyclic Triterpene from Humata tyermanni Moore with the Inhibitory Activities against LPS-Induced NO Production in RAW264.7 Macrophages
title_fullStr A New Pentacyclic Triterpene from Humata tyermanni Moore with the Inhibitory Activities against LPS-Induced NO Production in RAW264.7 Macrophages
title_full_unstemmed A New Pentacyclic Triterpene from Humata tyermanni Moore with the Inhibitory Activities against LPS-Induced NO Production in RAW264.7 Macrophages
title_sort new pentacyclic triterpene from humata tyermanni moore with the inhibitory activities against lps-induced no production in raw264.7 macrophages
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2013-01-01
description One new pentacyclic triterpene, hopane-22 (29)-en-24ol (2), with five known hopane-type pentacyclic triterpene compounds: hop-22(29)-ene (1), adiantone (3), 22-hydroxyhopane (4), 6α, 22-dihydroxyhopane (5), and 17(21)-hopene (6) were isolated from Humata tyermanni Moore. The structure of compound 2 was elucidated on the basis of its 1D and 2D NMR spectral analysis. All these compounds were evaluated for their inhibitory activities of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages.
url http://dx.doi.org/10.1155/2013/727136
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