In Vitro Demonstration of Focused Ultrasound Thrombolysis Using Bifrequency Excitation
Focused ultrasound involving inertial cavitation has been shown to be an efficient method to induce thrombolysis without any pharmacological agent. However, further investigation of the mechanisms involved and further optimization of the process are still required. The present work aims at studying...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2014-01-01
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| Series: | BioMed Research International |
| Online Access: | http://dx.doi.org/10.1155/2014/518787 |
| Summary: | Focused ultrasound involving inertial cavitation has been shown to be an
efficient method to induce thrombolysis without any pharmacological agent. However,
further investigation of the mechanisms involved and further optimization of the
process are still required. The present work aims at studying the relevance of a
bifrequency excitation compared to a classical monofrequency excitation to achieve
thrombolysis without any pharmacological agent. In vitro human blood clots were
placed at the focus of a piezoelectric transducer. Efficiency of the thrombolysis
was assessed by weighing each clot before and after sonication. The efficiencies of
mono- (550 kHz) and bifrequency (535 and 565 kHz) excitations were compared for
peak power ranging from 70 W to 220 W. The thrombolysis efficiency appears to be
correlated to the inertial cavitation activity quantified by passive acoustic listening.
In the conditions of the experiment, the power needed to achieve 80% of thrombolysis
with a monofrequency excitation is reduced by the half with a bifrequency excitation.
The thermal effects of bifrequency and monofrequency excitations, studied using MR
thermometry measurements in turkey muscle samples where no cavitation occurred,
did not show any difference between both types of excitations when using the same
power level. |
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| ISSN: | 2314-6133 2314-6141 |