Randomized trial of telephone versus in-person delivery of a brief psychosocial intervention in post-stroke depression

• Main Authors: Catherine J. Kirkness, Kevin C. Cain, Kyra J. Becker, David L. Tirschwell, Ann M. Buzaitis, Pamela L. Weisman, Sylvia McKenzie, Linda Teri, Ruth Kohen, Richard C. Veith, Pamela H. Mitchell
• Format: Article
• Language: English
• Published: BMC 2017-10-01
• Series: BMC Research Notes
• Subjects: Behavioural therapy; Psychosocial intervention; Depression; Randomized controlled trial; Stroke; Nurse therapist
• Online Access: http://link.springer.com/article/10.1186/s13104-017-2819-y

Abstract Background A psychosocial behavioral intervention delivered in-person by advanced practice nurses has been shown effective in substantially reducing post-stroke depression (PSD). This follow-up trial compared the effectiveness of a shortened intervention delivered by either telephone or in-person to usual care. To our knowledge, this is the first of current behavioral therapy trials to expand the protocol in a new clinical sample. 100 people with Geriatric Depression Scores ≥ 11 were randomized within 4 months of stroke to usual care (N = 28), telephone intervention (N = 37), or in-person intervention (N = 35). Primary outcome was response [percent reduction in the Hamilton Depression Rating Scale (HDRS)] and remission (HDRS score < 10) at 8 weeks and 12 months post treatment. Results Intervention groups were combined for the primary analysis (pre-planned). The mean response in HDRS scores was 39% reduction for the combined intervention group (40% in-person; 38% telephone groups) versus 33% for the usual care group at 8 weeks (p = 0.3). Remission occurred in 37% in the combined intervention groups at 8 weeks versus 27% in the control group (p = 0.3) and 44% intervention versus 36% control at 12 months (p = 0.5). While favouring the intervention, these differences were not statistically significant. Conclusions A brief psychosocial intervention for PSD delivered by telephone or in-person did not reduce depression significantly more than usual care. However, the comparable effectiveness of telephone and in-person follow-up for treatment of depression found is important given greater accessibility by telephone and mandated post-hospital follow-up for comprehensive stroke centers. Clinical Trial Registration URL: https://register.clinicaltrials.gov , unique identifier: NCT01133106, Registered 5/26/2010