Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates

Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates

Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4+ tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4+ Treg depletion. We have demonstrated that up to a 90% depletion was achieved and the depletion...

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Bibliographic Details
Main Authors: Zhaohui Wang, Nathan J. Louras, Alexandre G. Lellouch, Shannon G. Pratts, Huiping Zhang, Haoyu Wang, Christene A. Huang, Curtis L. Cetrulo Jr, Joren C. Madsen, David H. Sachs, Zhirui Wang
Format: Article
Language:English
Published: Wiley 2018-08-01
Series:Molecular Oncology
Subjects:
CCR4
diphtheria toxin
immunotoxin
Treg
Online Access:https://doi.org/10.1002/1878-0261.12331

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