PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

PARP1 and PARP2 of the PARP family enzymes are involved in DNA damage response. Here the authors report PARP2 activation mechanisms and its role in the formation of branched poly(ADP-ribose) chains in response to DNA damage.

Bibliographic Details
Main Authors: Qian Chen, Muzaffer Ahmad Kassab, Françoise Dantzer, Xiaochun Yu
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05588-5
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spelling doaj-3782bba392cb4d86addb32c7ae61f0ac2021-05-11T10:24:14ZengNature Publishing GroupNature Communications2041-17232018-08-019111310.1038/s41467-018-05588-5PARP2 mediates branched poly ADP-ribosylation in response to DNA damageQian Chen0Muzaffer Ahmad Kassab1Françoise Dantzer2Xiaochun Yu3Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical CenterDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical CenterUMR7242, Biotechnology and Cell Signaling, École Supérieure de Biotechnologie de Strasbourg, CNRS/Strasbourg UniversityDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical CenterPARP1 and PARP2 of the PARP family enzymes are involved in DNA damage response. Here the authors report PARP2 activation mechanisms and its role in the formation of branched poly(ADP-ribose) chains in response to DNA damage.https://doi.org/10.1038/s41467-018-05588-5
collection DOAJ
language English
format Article
sources DOAJ
author Qian Chen
Muzaffer Ahmad Kassab
Françoise Dantzer
Xiaochun Yu
spellingShingle Qian Chen
Muzaffer Ahmad Kassab
Françoise Dantzer
Xiaochun Yu
PARP2 mediates branched poly ADP-ribosylation in response to DNA damage
Nature Communications
author_facet Qian Chen
Muzaffer Ahmad Kassab
Françoise Dantzer
Xiaochun Yu
author_sort Qian Chen
title PARP2 mediates branched poly ADP-ribosylation in response to DNA damage
title_short PARP2 mediates branched poly ADP-ribosylation in response to DNA damage
title_full PARP2 mediates branched poly ADP-ribosylation in response to DNA damage
title_fullStr PARP2 mediates branched poly ADP-ribosylation in response to DNA damage
title_full_unstemmed PARP2 mediates branched poly ADP-ribosylation in response to DNA damage
title_sort parp2 mediates branched poly adp-ribosylation in response to dna damage
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description PARP1 and PARP2 of the PARP family enzymes are involved in DNA damage response. Here the authors report PARP2 activation mechanisms and its role in the formation of branched poly(ADP-ribose) chains in response to DNA damage.
url https://doi.org/10.1038/s41467-018-05588-5
work_keys_str_mv AT qianchen parp2mediatesbranchedpolyadpribosylationinresponsetodnadamage
AT muzafferahmadkassab parp2mediatesbranchedpolyadpribosylationinresponsetodnadamage
AT francoisedantzer parp2mediatesbranchedpolyadpribosylationinresponsetodnadamage
AT xiaochunyu parp2mediatesbranchedpolyadpribosylationinresponsetodnadamage
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