MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation.

MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation.

Although it is well known that epidermal growth factor receptor (EGFR) is involved in lung cancer progression, whether EGFR contributes to lung epithelial cell transformation is less clear. Mucin 1 (MUC1 in human and Muc1 in animals), a glycoprotein component of airway mucus, is overexpressed in lun...

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Bibliographic Details
Main Authors: Xiuling Xu, Lang Bai, Wenshu Chen, Mabel T Padilla, Yushi Liu, Kwang Chul Kim, Steven A Belinsky, Yong Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3310874?pdf=render

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