Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes

A model of stochastic time response of adsorption-based microfluidic biosensors is presented, that considers the competitive adsorption-desorption process coupled with mass transfer of two analytes. By using the model we analyze the expected value of the adsorbed particles number of each analyte, wh...

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Main Authors:	Ivana Jokić, Zoran Djurić, Katarina Radulović, Miloš Frantlović
Format:	Article
Language:	English
Published:	MDPI AG 2018-12-01
Series:	Proceedings
Subjects:	microfluidic sensor stochastic time response competitive adsorption mass transfer
Online Access:	https://www.mdpi.com/2504-3900/2/13/991

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spelling	doaj-3774065f414d484291931890fa479d2f2020-11-24T21:28:33ZengMDPI AGProceedings2504-39002018-12-0121399110.3390/proceedings2130991proceedings2130991Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two AnalytesIvana Jokić0Zoran Djurić1Katarina Radulović2Miloš Frantlović3ICTM—Institute of Microelectronic Technologies, University of Belgrade, 11000 Belgrade, SerbiaInstitute of Technical Sciences of SASA, Serbian Academy of Sciences and Arts, 11000 Belgrade, SerbiaICTM—Institute of Microelectronic Technologies, University of Belgrade, 11000 Belgrade, SerbiaICTM—Institute of Microelectronic Technologies, University of Belgrade, 11000 Belgrade, SerbiaA model of stochastic time response of adsorption-based microfluidic biosensors is presented, that considers the competitive adsorption-desorption process coupled with mass transfer of two analytes. By using the model we analyze the expected value of the adsorbed particles number of each analyte, which determine the sensor response kinetics. The comparison with the case when only one analyte exists is used for investigation of the influence of competitive adsorption on the sensor response. The response kinetics analyzed by using the stochastic model is compared with the kinetics predicted by the deterministic response model. The results are useful for optimization of micro/nanosensors intended for detection of substances in ultra-low concentrations in complex samples.https://www.mdpi.com/2504-3900/2/13/991microfluidic sensorstochastic time responsecompetitive adsorptionmass transfer
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ivana Jokić Zoran Djurić Katarina Radulović Miloš Frantlović
spellingShingle	Ivana Jokić Zoran Djurić Katarina Radulović Miloš Frantlović Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes Proceedings microfluidic sensor stochastic time response competitive adsorption mass transfer
author_facet	Ivana Jokić Zoran Djurić Katarina Radulović Miloš Frantlović
author_sort	Ivana Jokić
title	Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes
title_short	Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes
title_full	Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes
title_fullStr	Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes
title_full_unstemmed	Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes
title_sort	analysis of stochastic time response of microfluidic biosensors in the case of competitive adsorption of two analytes
publisher	MDPI AG
series	Proceedings
issn	2504-3900
publishDate	2018-12-01
description	A model of stochastic time response of adsorption-based microfluidic biosensors is presented, that considers the competitive adsorption-desorption process coupled with mass transfer of two analytes. By using the model we analyze the expected value of the adsorbed particles number of each analyte, which determine the sensor response kinetics. The comparison with the case when only one analyte exists is used for investigation of the influence of competitive adsorption on the sensor response. The response kinetics analyzed by using the stochastic model is compared with the kinetics predicted by the deterministic response model. The results are useful for optimization of micro/nanosensors intended for detection of substances in ultra-low concentrations in complex samples.
topic	microfluidic sensor stochastic time response competitive adsorption mass transfer
url	https://www.mdpi.com/2504-3900/2/13/991
work_keys_str_mv	AT ivanajokic analysisofstochastictimeresponseofmicrofluidicbiosensorsinthecaseofcompetitiveadsorptionoftwoanalytes AT zorandjuric analysisofstochastictimeresponseofmicrofluidicbiosensorsinthecaseofcompetitiveadsorptionoftwoanalytes AT katarinaradulovic analysisofstochastictimeresponseofmicrofluidicbiosensorsinthecaseofcompetitiveadsorptionoftwoanalytes AT milosfrantlovic analysisofstochastictimeresponseofmicrofluidicbiosensorsinthecaseofcompetitiveadsorptionoftwoanalytes
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Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes

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