MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and...

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Main Authors:	Sean M. Flynn, Changchun Chen, Murat Artan, Stephen Barratt, Alastair Crisp, Geoffrey M. Nelson, Sew-Yeu Peak-Chew, Farida Begum, Mark Skehel, Mario de Bono
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15872-y

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spelling	doaj-377402b6f41e4c2d90a5764edd0f5adf2021-05-11T08:24:40ZengNature Publishing GroupNature Communications2041-17232020-04-0111111510.1038/s41467-020-15872-yMALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevitySean M. Flynn0Changchun Chen1Murat Artan2Stephen Barratt3Alastair Crisp4Geoffrey M. Nelson5Sew-Yeu Peak-Chew6Farida Begum7Mark Skehel8Mario de Bono9Cell Biology Division, Medical Research Council Laboratory of Molecular BiologyCell Biology Division, Medical Research Council Laboratory of Molecular BiologyCell Biology Division, Medical Research Council Laboratory of Molecular BiologyCell Biology Division, Medical Research Council Laboratory of Molecular BiologyCell Biology Division, Medical Research Council Laboratory of Molecular BiologyCell Biology Division, Medical Research Council Laboratory of Molecular BiologyBiological Mass Spectrometry and Proteomics, Cell Biology Division, Medical Research Council Laboratory of Molecular BiologyBiological Mass Spectrometry and Proteomics, Cell Biology Division, Medical Research Council Laboratory of Molecular BiologyBiological Mass Spectrometry and Proteomics, Cell Biology Division, Medical Research Council Laboratory of Molecular BiologyCell Biology Division, Medical Research Council Laboratory of Molecular BiologyIL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and longevity.https://doi.org/10.1038/s41467-020-15872-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sean M. Flynn Changchun Chen Murat Artan Stephen Barratt Alastair Crisp Geoffrey M. Nelson Sew-Yeu Peak-Chew Farida Begum Mark Skehel Mario de Bono
spellingShingle	Sean M. Flynn Changchun Chen Murat Artan Stephen Barratt Alastair Crisp Geoffrey M. Nelson Sew-Yeu Peak-Chew Farida Begum Mark Skehel Mario de Bono MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity Nature Communications
author_facet	Sean M. Flynn Changchun Chen Murat Artan Stephen Barratt Alastair Crisp Geoffrey M. Nelson Sew-Yeu Peak-Chew Farida Begum Mark Skehel Mario de Bono
author_sort	Sean M. Flynn
title	MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
title_short	MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
title_full	MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
title_fullStr	MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
title_full_unstemmed	MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
title_sort	malt-1 mediates il-17 neural signaling to regulate c. elegans behavior, immunity and longevity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-04-01
description	IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and longevity.
url	https://doi.org/10.1038/s41467-020-15872-y
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MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

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