MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and...

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Bibliographic Details
Main Authors: Sean M. Flynn, Changchun Chen, Murat Artan, Stephen Barratt, Alastair Crisp, Geoffrey M. Nelson, Sew-Yeu Peak-Chew, Farida Begum, Mark Skehel, Mario de Bono
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15872-y
Description
Summary:IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and longevity.
ISSN:2041-1723

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