Reciprocal Roles of Angiotensin II and Angiotensin II Receptors Blockade (ARB) in Regulating Cbfa1/RANKL via cAMP Signaling Pathway: Possible Mechanism for Hypertension-Related Osteoporosis and Antagonistic Effect of ARB on Hypertension-Related Osteoporosis

Reciprocal Roles of Angiotensin II and Angiotensin II Receptors Blockade (ARB) in Regulating Cbfa1/RANKL via cAMP Signaling Pathway: Possible Mechanism for Hypertension-Related Osteoporosis and Antagonistic Effect of ARB on Hypertension-Related Osteoporosis

Hypertension is a risk factor for osteoporosis. Animal and epidemiological studies demonstrate that high blood pressure is associated with increased calcium loss, elevated parathyroid hormone, and increased calcium movement from bone. However, the mechanism responsible for hypertension-related osteo...

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Bibliographic Details
Main Authors: Ji-Yao Li, Yi Zhou, Xiao-Xu Guan
Format: Article
Language:English
Published: MDPI AG 2011-06-01
Series:International Journal of Molecular Sciences
Subjects:
hypertension
osteoporosis
angiotensin II
ARB
Cbfa1
RANKL
cAMP
Online Access:http://www.mdpi.com/1422-0067/12/7/4206/

Internet

http://www.mdpi.com/1422-0067/12/7/4206/

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