Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: <i>In Vitro</i>, <i>Ex Vivo</i>, and <i>In Silico</i> Studies

Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: <i>In Vitro</i>, <i>Ex Vivo</i>, and <i>In Silico</i> Studies

P-glycoprotein (P-gp) plays a crucial role in the protection of susceptible organs, by significantly decreasing the absorption/distribution of harmful xenobiotics and, consequently, their toxicity. Therefore, P-gp has been proposed as a potential antidotal pathway, when activated and/or induced. Kno...

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Bibliographic Details
Main Authors: Eva Martins, Vera Silva, Agostinho Lemos, Andreia Palmeira, Ploenthip Puthongking, Emília Sousa, Carolina Rocha-Pereira, Carolina I. Ghanem, Helena Carmo, Fernando Remião, Renata Silva
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
P-glycoprotein
induction
activation
oxygenated xanthones
intestinal barrier
intoxication scenarios
Online Access:https://www.mdpi.com/1420-3049/24/4/707

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