Evaluation of Organo [<sup>18</sup>F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers

Evaluation of Organo [<sup>18</sup>F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers

Fluorine-18 is the most widely used positron emission tomography (PET) radionuclide currently in clinical application, due to its optimal nuclear properties. The synthesis of <sup>18</sup>F-labeled radiotracers often requires harsh reaction conditions, limiting the use of sensitive bio-...

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Bibliographic Details
Main Authors: Sofia Otaru, Surachet Imlimthan, Mirkka Sarparanta, Kerttuli Helariutta, Kristiina Wähälä, Anu J. Airaksinen
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
fluorine-18
positron emission tomography (pet), defluorination
isotopic exchange
silicon-based fluoride acceptor
bioorthogonal chemistry
tetrazine
inverse electron-demand diels-alder ligation
Online Access:https://www.mdpi.com/1420-3049/25/5/1208

Internet

https://www.mdpi.com/1420-3049/25/5/1208

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