Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Sperm-egg fusion requires the interaction between IZUMO1 on the sperm and JUNO on the egg. Here, the authors report the crystal structure of mouse JUNO, and use it to explain its lack of binding to folate, along with in vivofunctional analyses.

Bibliographic Details
Main Authors: Kazuki Kato, Yuhkoh Satouh, Hiroshi Nishimasu, Arisa Kurabayashi, Junko Morita, Yoshitaka Fujihara, Asami Oji, Ryuichiro Ishitani, Masahito Ikawa, Osamu Nureki
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12198
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spelling doaj-3749d191acf74d07b435e8cb1bfa0c4f2021-05-11T10:52:47ZengNature Publishing GroupNature Communications2041-17232016-07-01711910.1038/ncomms12198Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilizationKazuki Kato0Yuhkoh Satouh1Hiroshi Nishimasu2Arisa Kurabayashi3Junko Morita4Yoshitaka Fujihara5Asami Oji6Ryuichiro Ishitani7Masahito Ikawa8Osamu Nureki9Department of Biological Sciences, Graduate School of Science, The University of TokyoResearch Institute for Microbial Diseases, Osaka University, 3-1 YamadaokaDepartment of Biological Sciences, Graduate School of Science, The University of TokyoDepartment of Biological Sciences, Graduate School of Science, The University of TokyoDepartment of Biological Sciences, Graduate School of Science, The University of TokyoResearch Institute for Microbial Diseases, Osaka University, 3-1 YamadaokaResearch Institute for Microbial Diseases, Osaka University, 3-1 YamadaokaDepartment of Biological Sciences, Graduate School of Science, The University of TokyoResearch Institute for Microbial Diseases, Osaka University, 3-1 YamadaokaDepartment of Biological Sciences, Graduate School of Science, The University of TokyoSperm-egg fusion requires the interaction between IZUMO1 on the sperm and JUNO on the egg. Here, the authors report the crystal structure of mouse JUNO, and use it to explain its lack of binding to folate, along with in vivofunctional analyses.https://doi.org/10.1038/ncomms12198
collection DOAJ
language English
format Article
sources DOAJ
author Kazuki Kato
Yuhkoh Satouh
Hiroshi Nishimasu
Arisa Kurabayashi
Junko Morita
Yoshitaka Fujihara
Asami Oji
Ryuichiro Ishitani
Masahito Ikawa
Osamu Nureki
spellingShingle Kazuki Kato
Yuhkoh Satouh
Hiroshi Nishimasu
Arisa Kurabayashi
Junko Morita
Yoshitaka Fujihara
Asami Oji
Ryuichiro Ishitani
Masahito Ikawa
Osamu Nureki
Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
Nature Communications
author_facet Kazuki Kato
Yuhkoh Satouh
Hiroshi Nishimasu
Arisa Kurabayashi
Junko Morita
Yoshitaka Fujihara
Asami Oji
Ryuichiro Ishitani
Masahito Ikawa
Osamu Nureki
author_sort Kazuki Kato
title Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
title_short Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
title_full Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
title_fullStr Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
title_full_unstemmed Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
title_sort structural and functional insights into izumo1 recognition by juno in mammalian fertilization
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-07-01
description Sperm-egg fusion requires the interaction between IZUMO1 on the sperm and JUNO on the egg. Here, the authors report the crystal structure of mouse JUNO, and use it to explain its lack of binding to folate, along with in vivofunctional analyses.
url https://doi.org/10.1038/ncomms12198
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AT yuhkohsatouh structuralandfunctionalinsightsintoizumo1recognitionbyjunoinmammalianfertilization
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