Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer

Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer

Purpose: Enhancing immune responses in triple negative breast cancers (TNBCs) remains a challenge. Our study aimed to determine whether magnetic iron oxide nanoparticle (MION) hyperthermia (HT) can enhance abscopal effects with radiotherapy (RT) and immune checkpoint inhibitors (IT) in a metastatic...

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Bibliographic Details
Main Authors: Arlene L. Oei, Preethi Korangath, Kathleen Mulka, Mikko Helenius, Jonathan B. Coulter, Jacqueline Stewart, Esteban Velarde, Johannes Crezee, Brian Simons, Lukas J. A. Stalpers, H. Petra Kok, Kathleen Gabrielson, Nicolaas A. P. Franken, Robert Ivkov
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:International Journal of Hyperthermia
Subjects:
magnetic nanoparticle hyperthermia
triple negative breast cancer
immune checkpoint therapy
ionizing radiation
metastatic cancer
Online Access:http://dx.doi.org/10.1080/02656736.2019.1685686

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