Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game

Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game

The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyanuric chloride (TCT). The preferential order of incorporation of different nucleophiles (such as alcohol, thiol, and amine) was addressed both experimentally and theoretically. The preferential order...

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Bibliographic Details
Main Authors: Anamika Sharma, Ayman El-Faham, Beatriz G. de la Torre, Fernando Albericio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Chemistry
Subjects:
s-triazine
triorthogonal linker
density functional theory
NBO calculations
electrostatic potential maps
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00516/full

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