Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients

Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients

Highlights 1. Gene transcript profiles in the elderly AML patients are different from those in young patients. 2. Statistical analysis reveals the down-regulation of protein processing in ER and pathways related to immunity in elderly patients. 3. GEO and GSEA analyses demonstrate the genes of cance...

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Main Authors: Jizhang Bao, Xinhua Zhao, Jiahui Lu, Zhaoyang Hu, Minghui Hu, Xiaoxia Hu, Libing Wang, Qi Hu, Weiling Sun, Jie Wang, Hailin Chen, Hao Lu, Changgui Li, Jing Xu, Yongming Zhou, Wenwei Zhu
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Translational Medicine
Subjects:
Acute myeloid leukemia
Platelet RNA sequencing
Mitogen activated protein kinase
Activating transcription factor 4
Online Access:https://doi.org/10.1186/s12967-021-03041-8
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spelling doaj-373346b1283e43cc8bbe436e08f4a2142021-09-12T11:06:53ZengBMCJournal of Translational Medicine1479-58762021-09-0119111110.1186/s12967-021-03041-8Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patientsJizhang Bao0Xinhua Zhao1Jiahui Lu2Zhaoyang Hu3Minghui Hu4Xiaoxia Hu5Libing Wang6Qi Hu7Weiling Sun8Jie Wang9Hailin Chen10Hao Lu11Changgui Li12Jing Xu13Yongming Zhou14Wenwei Zhu15The Hematological Dept., Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineBasic Medical College, Shanghai University of Traditional Chinese MedicineThe Hematological Dept., Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineFun-Med Pharmaceutical Technology (Shanghai) Co., Ltd.The Hematological Dept., Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineDepartment of Hematology, Changhai HospitalDepartment of Hematology, Changhai HospitalThe Hematological Dept., Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineThe Hematological Dept., Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineThe Hematological Dept., Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineThe Hematological Dept., Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineThe Hematological Dept., Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineThe Hematological Dept., Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineThe Hematological Dept., Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineThe Hematological Dept., Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineThe Hematological Dept., Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineHighlights 1. Gene transcript profiles in the elderly AML patients are different from those in young patients. 2. Statistical analysis reveals the down-regulation of protein processing in ER and pathways related to immunity in elderly patients. 3. GEO and GSEA analyses demonstrate the genes of cancer pathway and mitogen activated protein kinase (MAPK) pathway, involved in natural immunity and metabolism, are largely down-regulated in elderly patients. 4. ATF4 is a biomarker indicating different therapeutic strategies for elderly patients.https://doi.org/10.1186/s12967-021-03041-8Acute myeloid leukemiaPlatelet RNA sequencingMitogen activated protein kinaseActivating transcription factor 4
collection DOAJ
language English
format Article
sources DOAJ
author Jizhang Bao
Xinhua Zhao
Jiahui Lu
Zhaoyang Hu
Minghui Hu
Xiaoxia Hu
Libing Wang
Qi Hu
Weiling Sun
Jie Wang
Hailin Chen
Hao Lu
Changgui Li
Jing Xu
Yongming Zhou
Wenwei Zhu
spellingShingle Jizhang Bao
Xinhua Zhao
Jiahui Lu
Zhaoyang Hu
Minghui Hu
Xiaoxia Hu
Libing Wang
Qi Hu
Weiling Sun
Jie Wang
Hailin Chen
Hao Lu
Changgui Li
Jing Xu
Yongming Zhou
Wenwei Zhu
Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients
Journal of Translational Medicine
Acute myeloid leukemia
Platelet RNA sequencing
Mitogen activated protein kinase
Activating transcription factor 4
author_facet Jizhang Bao
Xinhua Zhao
Jiahui Lu
Zhaoyang Hu
Minghui Hu
Xiaoxia Hu
Libing Wang
Qi Hu
Weiling Sun
Jie Wang
Hailin Chen
Hao Lu
Changgui Li
Jing Xu
Yongming Zhou
Wenwei Zhu
author_sort Jizhang Bao
title Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients
title_short Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients
title_full Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients
title_fullStr Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients
title_full_unstemmed Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients
title_sort platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients
publisher BMC
series Journal of Translational Medicine
issn 1479-5876
publishDate 2021-09-01
description Highlights 1. Gene transcript profiles in the elderly AML patients are different from those in young patients. 2. Statistical analysis reveals the down-regulation of protein processing in ER and pathways related to immunity in elderly patients. 3. GEO and GSEA analyses demonstrate the genes of cancer pathway and mitogen activated protein kinase (MAPK) pathway, involved in natural immunity and metabolism, are largely down-regulated in elderly patients. 4. ATF4 is a biomarker indicating different therapeutic strategies for elderly patients.
topic Acute myeloid leukemia
Platelet RNA sequencing
Mitogen activated protein kinase
Activating transcription factor 4
url https://doi.org/10.1186/s12967-021-03041-8
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