| Summary: | This work evaluates the physicochemical properties and fatty acids profile of Sesamum indicum (SSiO) and Vicia faba (SVfO) seed oils, and studies the anti-hyperlipidemic activity of the composite oil (CO) of the seed oils in high lipid diet (HLD) induced male Wistar rats. To investigate the anti-hyperlipidemic activity of the CO, the rats were randomly assigned into six groups: group-I (control), group-II (HLD), group-III (HLD+CO-100 mg/kg), group-IV (HLD+CO-200 mg/kg), group-V (HLD+CO-400 mg/kg), and group-VI (HLD+atorvastatin-10 mg/kg). We found that the SSiO contained highest proportion of total polyunsaturated fatty acid (42.18%) and lowest proportion of total saturated fatty acid (16.21%), while the SVfO reflected highest total monounsaturated fatty acid (49.48%). In addition, the SSiO contained a high amount of oleic (41.30%) and linoleic acid (41.92%), whereas the SVfO contained a high amount of eicosenoic acid (44.26%). The administration of all the CO doses demonstrated a significant decrease in triglyceride, total cholesterol, low-density lipoprotein cholesterol, apolipoprotein-B, and malondialdehyde, and a significant increase in high-density lipoprotein cholesterol, apolipoprotein-A1, superoxide dismutase, and catalase levels. The CO was also effective in histopathological changes in adipose tissue. The promising findings indicate that the CO has potential utility as a natural supplement and functional food to prevent hyperlipidemia.
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