Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways

Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways

Dectin-1 is a C-type lectin receptor critical in anti-fungal immunity, but Dectin-1 has not been linked to regulation of sterile inflammation or oncogenesis. We found that Dectin-1 expression is upregulated in hepatic fibrosis and liver cancer. However, Dectin-1 deletion exacerbates liver fibro-infl...

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Bibliographic Details
Main Authors: Lena Seifert, Michael Deutsch, Sara Alothman, Dalia Alqunaibit, Gregor Werba, Mridul Pansari, Matthew Pergamo, Atsuo Ochi, Alejandro Torres-Hernandez, Elliot Levie, Daniel Tippens, Stephanie H. Greco, Shaun Tiwari, Nancy Ngoc Giao Ly, Andrew Eisenthal, Eliza van Heerden, Antonina Avanzi, Rocky Barilla, Constantinos P. Zambirinis, Mauricio Rendon, Donnele Daley, H. Leon Pachter, Cristina Hajdu, George Miller
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Subjects:
liver fibrosis
hepatocellular cancer
C-type lectin receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715012474

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http://www.sciencedirect.com/science/article/pii/S2211124715012474

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