Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor

Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor

The liver kinase B1 (LKB1) tumour suppressor functions as a master regulator of growth, metabolism and survival in cells, which is frequently mutated in sporadic human non-small cell lung and cervical cancers. LKB1 functions as a key upstream activator of the AMP-activated protein kinase (AMPK), a c...

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Bibliographic Details
Main Author: David B Shackelford
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Carcinogenesis
Subjects:
AMP-activated protein kinase
fluoro-deoxyglucose positron emission tomography
liver kinase B1
mammalian target of rapamycin complex 1
therapeutics
Warburg
Online Access:http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=16;epage=16;aulast=Shackelford

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http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=16;epage=16;aulast=Shackelford

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