Anxiolytic and thrombolytic investigation of methanol extract of Piper nigrum L. fruits and Sesamum indicum L. seeds

• Main Authors: Nazim Uddin Emon, Md Kaiser, Mohammed Faisal Ibna Kabir, Mohammad Jamir Uddin, Mifta Ahmed Jyoti, Saifullah Mansur Tanjil, Abu Nayem Mohammad Rasel, Safaet Alam, Mohammad Nazmul Islam
• Format: Article
• Language: English
• Published: Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology 2020-12-01
• Series: Journal of Advanced Biotechnology and Experimental Therapeutics
• Subjects: piper nigrum; sesamum indicum; streptokinase; thrombolytic; anxiolytic activity
• Online Access: http://www.ejmanager.com/fulltextpdf.php?mno=98631

The study was intended to compare and evaluate the in vitro thrombolytic activity and in vivo anxiolytic activities of methanol extracts of Piper nigrum fruits (MEPNF) and Sesamum indicum seeds (MESIS). An in vitro thrombolytic activity was employed by investigating the clot lysis effect of MEPNF, MESIS, and their combinations. In vivo anxiolytic activity of MEPNF and MESIS was examined by using the Elevated Plus Maze (EPM) test considering diazepam (1 mg/kg) as the standard drug. In the thrombolytic test, MEPNF and MESIS showed a moderate (P < 0.1) clot lysis activity. Besides, MEPNF and MESIS showed significant (P < 0.001) dose-dependent anxiolytic activity. Since MEPNF 200 and 400 (mg/kg, b.w; p.o) was administered, the time spent in the open arms, and the number of entry into the open arms were increased. The finding suggests that MEPNF and MESIS may be the source for biological activity and therefore further research is required for confirmation. [ J Adv Biotechnol Exp Ther 2020; 3(3.000): 158-164]