Mitochondrial dysfunction and endoplasmic reticulum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes

Mitochondrial dysfunction and endoplasmic reticulum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes

Abstract Object To explore the mechanisms of ovarian aging, we performed overall analysis on the age-related alterations of gene expression profiles in mouse germinal vesicle (GV) stage oocytes by means of single-cell RNA-sequencing method (scRNA-seq). Methods Two age groups (5-week-old and 32-week-...

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Bibliographic Details
Main Authors: Tao Zhang, Qingsong Xi, Dan Wang, Jingjing Li, Meng Wang, Dan Li, Lixia Zhu, Lei Jin
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Ovarian Research
Subjects:
Ovarian aging
Single-cell RNA-sequencing
Oocyte
Mitochondria
Complex I
Endoplasmic reticulum stress
Online Access:http://link.springer.com/article/10.1186/s13048-019-0529-x

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