ROLE OF HEREDITARY FACTORS IN THE DEVELOPMENT OF GLIAL BRAIN TUMORS
Background. The analysis data on the malignant neoplasms incidence among first-degree relatives of probands with glial brain tumors are presented. Goal. To study the incidence of malignant neoplasms among first-degree relatives of probands with malignant glial brain tumors for determining the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Belarusian |
| Published: |
Grodno State Medical University
2018-11-01
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| Series: | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| Subjects: | |
| Online Access: | http://journal-grsmu.by/index.php/ojs/article/view/2321/2119 |
| Summary: | Background. The analysis data on the malignant neoplasms incidence among first-degree relatives of probands
with glial brain tumors are presented.
Goal. To study the incidence of malignant neoplasms among first-degree relatives of probands with malignant glial
brain tumors for determining the genetic component value.
Material and methods. We used the indices of population incidence of malignant neoplasms among the residents
of Belarus and estimated incidence rates among first-degree relatives of patients in the time interval corresponding to
the average lifespan of the population of Belarus.
Results. According to the given analysis, first-degree relatives have an increased risk of brain, rectal, thyroid gland
and uterine body malignant neoplasms. However, a statistically significant risk was found only for malignant brain
neoplasms. The standardized incidence among first-degree relatives in such localization was 3.39 (95% CI 1.10 -
7.92), which corresponds to the results obtained by specialists from other countries (USA, Sweden, etc.).
Conclusions. The value of the genetic component of glial brain tumors in first-degree relatives of probands with
established malignant glial brain neoplasms was 70.5% (95% CI 9.0 - 87.4%). |
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| ISSN: | 2221-8785 2413-0109 |