A pilot study evaluating GSK1070806 inhibition of interleukin-18 in renal transplant delayed graft function.

A pilot study evaluating GSK1070806 inhibition of interleukin-18 in renal transplant delayed graft function.

<h4>Introduction</h4>Delayed graft function (DGF) following renal transplantation is a manifestation of acute kidney injury (AKI) leading to poor long-term outcome. Current treatments have limited effectiveness in preventing DGF. Interleukin-18 (IL18), a biomarker of AKI, induces interfe...

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Bibliographic Details
Main Authors: E Wlodek, R B Kirkpatrick, S Andrews, R Noble, R Schroyer, J Scott, C J E Watson, M Clatworthy, E M Harrison, S J Wigmore, K Stevenson, D Kingsmore, N S Sheerin, O Bestard, H A Stirnadel-Farrant, L Abberley, M Busz, S DeWall, M Birchler, D Krull, K S Thorneloe, A Weber, L Devey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0247972

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