Osteoblast suppression in multiple myeloma bone disease

Multiple myeloma (MM) is the most frequent cancer to involve the skeleton with patients developing osteolytic bone lesions due to hyperactivation of osteoclasts and suppression of BMSCs differentiation into functional osteoblasts. Although new therapies for MM have greatly improved survival, MM rema...

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Bibliographic Details
Main Authors: Juraj Adamik, Deborah L Galson, G David Roodman
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Journal of Bone Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137418301106