The IFITMs Inhibit Zika Virus Replication

The IFITMs Inhibit Zika Virus Replication

Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here, we show that IFITM1 and IFITM3 inhibit Zika...

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Main Authors: George Savidis, Jill M. Perreira, Jocelyn M. Portmann, Paul Meraner, Zhiru Guo, Sharone Green, Abraham L. Brass
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Subjects:
Zika virus
flavivirus
host factors
IFITM
IFITM1
IFITM3
intrinsic immunity
interferon
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306878
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spelling doaj-3708ab9df5654983b876c46a7954213f2020-11-24T21:34:40ZengElsevierCell Reports2211-12472016-06-0115112323233010.1016/j.celrep.2016.05.074The IFITMs Inhibit Zika Virus ReplicationGeorge Savidis0Jill M. Perreira1Jocelyn M. Portmann2Paul Meraner3Zhiru Guo4Sharone Green5Abraham L. Brass6Department of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USADepartment of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USADepartment of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USADepartment of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USADivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USADivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USADepartment of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USAZika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here, we show that IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. Moreover, IFITM3 can prevent Zika-virus-induced cell death. These results suggest that strategies to boost the actions and/or levels of the IFITMs might be useful for inhibiting a broad range of emerging viruses.http://www.sciencedirect.com/science/article/pii/S2211124716306878Zika virusflavivirushost factorsIFITMIFITM1IFITM3intrinsic immunityinterferon
collection DOAJ
language English
format Article
sources DOAJ
author George Savidis
Jill M. Perreira
Jocelyn M. Portmann
Paul Meraner
Zhiru Guo
Sharone Green
Abraham L. Brass
spellingShingle George Savidis
Jill M. Perreira
Jocelyn M. Portmann
Paul Meraner
Zhiru Guo
Sharone Green
Abraham L. Brass
The IFITMs Inhibit Zika Virus Replication
Cell Reports
Zika virus
flavivirus
host factors
IFITM
IFITM1
IFITM3
intrinsic immunity
interferon
author_facet George Savidis
Jill M. Perreira
Jocelyn M. Portmann
Paul Meraner
Zhiru Guo
Sharone Green
Abraham L. Brass
author_sort George Savidis
title The IFITMs Inhibit Zika Virus Replication
title_short The IFITMs Inhibit Zika Virus Replication
title_full The IFITMs Inhibit Zika Virus Replication
title_fullStr The IFITMs Inhibit Zika Virus Replication
title_full_unstemmed The IFITMs Inhibit Zika Virus Replication
title_sort ifitms inhibit zika virus replication
publisher Elsevier
series Cell Reports
issn 2211-1247
publishDate 2016-06-01
description Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here, we show that IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. Moreover, IFITM3 can prevent Zika-virus-induced cell death. These results suggest that strategies to boost the actions and/or levels of the IFITMs might be useful for inhibiting a broad range of emerging viruses.
topic Zika virus
flavivirus
host factors
IFITM
IFITM1
IFITM3
intrinsic immunity
interferon
url http://www.sciencedirect.com/science/article/pii/S2211124716306878
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