Comparative Molecular Dynamics Simulations of Mitogen-Activated Protein Kinase-Activated Protein Kinase 5

Comparative Molecular Dynamics Simulations of Mitogen-Activated Protein Kinase-Activated Protein Kinase 5

The mitogen-activated protein kinase-activated protein kinase MK5 is a substrate of the mitogen-activated protein kinases p38, ERK3 and ERK4. Cell culture and animal studies have demonstrated that MK5 is involved in tumour suppression and promotion, embryogenesis, anxiety, cell motility and cell cyc...

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Bibliographic Details
Main Authors: Inger Lindin, Yimingjiang Wuxiuer, Aina Westrheim Ravna, Ugo Moens, Ingebrigt Sylte
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:International Journal of Molecular Sciences
Subjects:
MAPKAPK5
MK5
PRAK
homology modelling
protein-ligand complexes
p38α
protein-protein interactions
molecular dynamics simulations
molecular mechanisms
electrostatic potential surfaces
Online Access:http://www.mdpi.com/1422-0067/15/3/4878

Internet

http://www.mdpi.com/1422-0067/15/3/4878

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