Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer

Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer

Abstract Background Human pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune checkpoint inhibitor (ICPi). While the mechanism is not completely clear, it has been recognized that tumor microenvironment (TME) plays key roles. We investigated if targeting CD47 with a monoclonal antibody...

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Bibliographic Details
Main Authors: Yu Pan, Fengchun Lu, Qinglin Fei, Xingxing Yu, Ping Xiong, Xunbin Yu, Yuan Dang, Zelin Hou, Wenji Lin, Xianchao Lin, Zheyang Zhang, Minggui Pan, Heguang Huang
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Hematology & Oncology
Subjects:
CD47
PD-L1
Immunotherapy
Pancreatic cancer
Immune checkpoint inhibitor
Online Access:http://link.springer.com/article/10.1186/s13045-019-0822-6

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