Effect of Statin Therapy on Diabetes Retinopathy in People With Type 2 Diabetes Mellitus: A Meta-Analysis

Objective: We tried to find the relationship between statin and diabetes retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Methods: We searched the databases of PubMed, EMBASE, and the Cochrane Library for eligible studies reporting on the relationships between statin use and DR, fr...

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Main Authors: Jun Liu MD, Yi-Ping Wu MD, Jun-Juan Qi MD, Zeng-Ping Yue MD, Cheng-Dong Hu MD
Format: Article
Language:English
Published: SAGE Publishing 2021-10-01
Series:Clinical and Applied Thrombosis/Hemostasis
Online Access:https://doi.org/10.1177/10760296211040109
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spelling doaj-36e5fc7139f548298456aa724067e6b32021-10-07T23:03:18ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232021-10-012710.1177/10760296211040109Effect of Statin Therapy on Diabetes Retinopathy in People With Type 2 Diabetes Mellitus: A Meta-AnalysisJun Liu MD0Yi-Ping Wu MD1Jun-Juan Qi MD2Zeng-Ping Yue MD3Cheng-Dong Hu MD4 Handan Central Hospital, Handan, Hebei Province, China Handan Central Hospital, Handan, Hebei Province, China Handan Central Hospital, Handan, Hebei Province, China Handan Central Hospital, Handan, Hebei Province, China Handan Central Hospital, Handan, Hebei Province, ChinaObjective: We tried to find the relationship between statin and diabetes retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Methods: We searched the databases of PubMed, EMBASE, and the Cochrane Library for eligible studies reporting on the relationships between statin use and DR, from inception to September 25, 2020. The terms searched including Diabetes Mellitus, Type 2, Hydroxymethylglutaryl-CoA Reductase Inhibitors, and Diabetic Retinopathy. We expressed the results as the odds ratios (ORs) with 95% confidence intervals (CIs) which were calculated using a random-effects model. Results: A total of 6 eligible studies, including 43 826 patients, were included in the meta-analysis. The meta-analysis showed that statin was not associated with elevated risk of DR [OR = 0.96 (95% CI: 0.80-1.16), P  = .68]. Similarly, no differences were found between statin and placebo in participants ≥500 [OR = 0.98 (95% CI: 0.80-1.21)] or participants <500 [OR = 0.90 (95% CI: 0.49-1.66)]. Further, we conducted a meta-analysis to study the effect of statin therapy on DR in people with type 2 diabetes according to age and found that statin use was associated with a decreased risk of DR in patients with type 2 diabetes 40 years of age or older [OR = 0.87 (95% CI: 0.82-0.92)]. Conclusion: Our meta-analysis revealed that statin was not associated with elevated risk of DR in patients with T2DM. Moreover, statin use was associated with a lower incidence of DR in patients with type 2 diabetes 40 years of age or older.https://doi.org/10.1177/10760296211040109
collection DOAJ
language English
format Article
sources DOAJ
author Jun Liu MD
Yi-Ping Wu MD
Jun-Juan Qi MD
Zeng-Ping Yue MD
Cheng-Dong Hu MD
spellingShingle Jun Liu MD
Yi-Ping Wu MD
Jun-Juan Qi MD
Zeng-Ping Yue MD
Cheng-Dong Hu MD
Effect of Statin Therapy on Diabetes Retinopathy in People With Type 2 Diabetes Mellitus: A Meta-Analysis
Clinical and Applied Thrombosis/Hemostasis
author_facet Jun Liu MD
Yi-Ping Wu MD
Jun-Juan Qi MD
Zeng-Ping Yue MD
Cheng-Dong Hu MD
author_sort Jun Liu MD
title Effect of Statin Therapy on Diabetes Retinopathy in People With Type 2 Diabetes Mellitus: A Meta-Analysis
title_short Effect of Statin Therapy on Diabetes Retinopathy in People With Type 2 Diabetes Mellitus: A Meta-Analysis
title_full Effect of Statin Therapy on Diabetes Retinopathy in People With Type 2 Diabetes Mellitus: A Meta-Analysis
title_fullStr Effect of Statin Therapy on Diabetes Retinopathy in People With Type 2 Diabetes Mellitus: A Meta-Analysis
title_full_unstemmed Effect of Statin Therapy on Diabetes Retinopathy in People With Type 2 Diabetes Mellitus: A Meta-Analysis
title_sort effect of statin therapy on diabetes retinopathy in people with type 2 diabetes mellitus: a meta-analysis
publisher SAGE Publishing
series Clinical and Applied Thrombosis/Hemostasis
issn 1938-2723
publishDate 2021-10-01
description Objective: We tried to find the relationship between statin and diabetes retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Methods: We searched the databases of PubMed, EMBASE, and the Cochrane Library for eligible studies reporting on the relationships between statin use and DR, from inception to September 25, 2020. The terms searched including Diabetes Mellitus, Type 2, Hydroxymethylglutaryl-CoA Reductase Inhibitors, and Diabetic Retinopathy. We expressed the results as the odds ratios (ORs) with 95% confidence intervals (CIs) which were calculated using a random-effects model. Results: A total of 6 eligible studies, including 43 826 patients, were included in the meta-analysis. The meta-analysis showed that statin was not associated with elevated risk of DR [OR = 0.96 (95% CI: 0.80-1.16), P  = .68]. Similarly, no differences were found between statin and placebo in participants ≥500 [OR = 0.98 (95% CI: 0.80-1.21)] or participants <500 [OR = 0.90 (95% CI: 0.49-1.66)]. Further, we conducted a meta-analysis to study the effect of statin therapy on DR in people with type 2 diabetes according to age and found that statin use was associated with a decreased risk of DR in patients with type 2 diabetes 40 years of age or older [OR = 0.87 (95% CI: 0.82-0.92)]. Conclusion: Our meta-analysis revealed that statin was not associated with elevated risk of DR in patients with T2DM. Moreover, statin use was associated with a lower incidence of DR in patients with type 2 diabetes 40 years of age or older.
url https://doi.org/10.1177/10760296211040109
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