PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population.

PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population.

Founder populations and large pedigrees offer many well-known advantages for genetic mapping studies, including cost-efficient study designs. Here, we describe PRIMAL (PedigRee IMputation ALgorithm), a fast and accurate pedigree-based phasing and imputation algorithm for founder populations. PRIMAL...

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Bibliographic Details
Main Authors: Oren E Livne, Lide Han, Gorka Alkorta-Aranburu, William Wentworth-Sheilds, Mark Abney, Carole Ober, Dan L Nicolae
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4348507?pdf=render

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