The effects of hydroalcoholic extract of Portulaca Oleracea on the serum concentreation of Hepatic enzymes in Rats

• Main Authors: Ali Zarei, Saeed Changizi Ashtiyani, Soheila Taheri
• Format: Article
• Language: English
• Published: Bushehr University of Medical Sciences 2014-11-01
• Series: Iranian South Medical Journal
• Subjects: Atorvastatin; ALT; AST; ALP; Portulaca Oleracea; Rat
• Online Access: http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-519&slc_lang=en&sid=1

Background Hyperlipidemia can be cause a variety of diseases such as atherosclerosis, diabetes and fatty liver and subsequent liver enzyme increases. The Portulaca Oleracea plant has hypoglycemic and hypolipidemic properties. Therefore, in this study the effect of Portulca Oleracea herb extract on serum liver enzymes including aspartate aminotransferase (SGOT or AST), alanine aminotransferase (SGPT or ALT) and alkaline phosphatase (ALP) in rats were studied. Materials and Methods: In this experimental study, 60 Wistar rats were divided into 6 groups (n=10). Control group with normal diet, fat diet group and other groups, the experimental group received the same diet plus fat Portulaca oleracea extract maximum dose (800), the mean dose of (400), and a minimum dose of (200 mg / kg) or intraperitoneally injection (ip) and sort of Atorvastatin (10 mg kg). After the end of this period (21 days), blood sampling was performed and collected data were analyzed using the t and Tukey test, and SPSS software version 11.5. Results Comparison of statistical results indicated that alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) increase in the control group that received only fatty foods, while the experimental groups received extract of Portulaca Oleracea, and groups receiving Atorvastatin had reduced levels of liver enzymes. Conclusion: Regarding hypoglycemic and hypolipidemic antioxidant activity of the extract and its effect on reducing liver enzymes, plant extracts can be recommended to improve liver function.